Archive for RNA

june 2015

injecting electronic scaffolds into the brain

Injectable device delivers nano-view of the brain
Harvard Gazette — June 8, 2015

  • Discovery of a way to inject nanofabricated electronic scaffolds into the brain without causing inflammation.
  • Scaffolds, etched like microchips, can be precisely located to monitor and stimulate tissue processes and regenerate neurons. They are flexible and “like to interact with neurons.”

new techniques for profiling a single cell

Beyond Average
Stephanie Dutchen, Harvard Medical News — May 21, 2015

  • “Different cells in a tissue use the same genome in amazingly diverse ways…”
  • …”even embryonic stem cells are not uniform…”
  • Thousands of single cell profiles can be generated per day using the Drop-Seq and inDrops techniques. This is up from the previous profile generation rate of 96 single cell profiles per day.

Single-cell analysis hits its stride
Lisa Girard, Broad Communications — May 21, 2015

  • Analyzing variations between the same cell type is faster and more straightforward now that each cell can be assigned a unique DNA barcode.
  • Microfluidic techniques allow each cell to interact with an outside DNA fragment. The DNA breaks up the cell and “reverse transcribes” the cell’s mRNA into a unique DNA barcode.
  • When the tissue cells are sequenced and sorted, variation can be traced back to an individual cell using its barcode.
  • Labs can buy droplets with DNA fragments for use in barcoding for 6 cents each.

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april 2015: 2

Bicarbonate for Better Vision?
“Controlling bicarbonate levels may slow progression of eye diseases”
Harvard Medical School News — April 2, 2015

Evolutionary Relic
Pseudogenes in the human genome may lead to cancer development”
Harvard Medical School News — April 2, 2015

New function of obesity gene revealed
University of Oxford — April 17, 2015

Scientists discover protein that boosts immunity to viruses and cancer
Imperial College London — 16 April 16, 2015

environment

Major Advance in Artificial Photosynthesis Poses Win/Win for the Environment
“Berkeley Lab Researchers Perform Solar-powered Green Chemistry with Captured CO2”

physics

Thousands of atoms entangled with a single photon
“Result could make atomic clocks more accurate”
MIT News Office — March 26, 2015

Using sound waves to detect rare cancer cells
“Acoustic device can rapidly isolate circulating tumor cells from patient blood samples”
MIT News Office — April 6, 2015

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January 2015:3

New analysis explains collagen’s force
“Experiments and simulations show that adding or removing water makes the material push and pull”
David L. Chandler, MIT News Office — January 22, 2015

Ribose-seq identifies and locates ribonucleotides in genomic DNA
New ribose-seq technique allows access to the full profile of ribonucleotides embedded in genomic DNA
Georgia Tech News Center, Health and Medicine — January 26, 2015

Telomere extension turns back aging clock in cultured human cells, study finds
“Researchers delivered a modified RNA that encodes a telomere-extending protein to cultured human cells”
Krista Conger, Stanford Medicine News Center — January 22, 2015

cell mechanics: transcription and replication

Genetic switch regulates transcription and replication in human mitochondria
Heather Zeiger, Phys.org, Cell & Microbiology — February 2, 2015

In a role reversal, RNAs proofread themselves
“Molecular photographs of an enzyme bound to RNA reveal a new, inherent quality control mechanism”
Cold Spring Harbor Laboratory — January 29, 2015

Variety show
“New techniques reveal ‘extreme’ gene copy range”
Stephanie Dutchen, Harvard Medical News — January 29, 2015

mathematics 

The Pursuit of Beauty
“Yitang Zhang solves a pure-math mystery”
Alec Wilkinson, New Yorker — February 2, 2015

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March 2014: 2

A paper diagnostic for cancer
“Low-cost urine test developed by MIT engineers amplifies signals from growing tumors to detect disease”
Anne Trafton, MIT News Office — February 24, 2014

Artificial muscles that do the twist
“Researchers develop a bioinspired, actuated material that mimics the complex motion of heart muscle”
Kristen Kusek, Wyss Institute Communications, Harvard University — February 26, 2014

Lessening liver damage
“Scientists believe they’ve found improved treatment for acetaminophen poisoning”
Joseph Caputo, Harvard Gazette — February 19, 2014

Sharper Image
“Researchers capture ultrasharp images of multiple cell components at once”
Dan Ferber, Harvard Medical News — February 3, 2014

Turning back the clock on aging muscles?
“New study supports the possibility of localized rejuvenation”
Institute of Biomaterials & Biomedical Engineering, University of Toronto — February 16, 2014

Imaging within cells (two versions)

A bird’s eye view of cellular RNAs
Dan Ferber, Wyss Institute Communications, Harvard University — February 27, 2014

Location, Location, Location
“New method IDs working copies of genes in human cells; could help diagnose sick tissues early”
Dan Ferber, Harvard Medicine news — February 28, 2014

 

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March 2014: 1

An Essential Step toward Printing Living Tissues
Dan Ferber, Press Contact, Wyss Institute, Harvard University — February 19, 2014

Cell cycle speed is key to making aging cells young again
Bill Hathaway, Yale University news — January 30, 2014

Critical protein discovered for healthy cell growth in mammals
Krista Weidner, Penn State News  — January 27, 2014

DNA-built Nanoparticles Safely Target Cancer Tumours
Institute of Biomaterials & Biomedical Engineering, University of Toronto — January 28, 2014

Gene editing (see previous posts below for more on gene editing)

Better RNA interference, inspired by nature
“New … nanoparticles offer best-ever gene silencing, could help treat liver diseases”
Anne Trafton, MIT News Office — February 10, 2014

Broad, MIT researchers reveal structure of key CRISPR complex
Correcting errors in the genome with an editing tool
Veronica Meade-Kelly, Broad Institute Communications — February 13th, 2014

New Insight into an Emerging Genome-Editing Tool
“Berkeley Researchers Show Expanded Role for Guide RNA in Cas9 Interactions with DNA”
Lynn Yarris, Lawrence Berkeley National Laboratory News Center — February 6, 2014

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February 2014: 3

Hitchhiking vaccines boost immunity
“New MIT vaccines that catch a ride to immune cell depots could help fight cancer and HIV”
Anne Trafton, MIT News Office — February 16, 2014

Molecular aberration signals cancer
Investigating the role of noncoding RNA
Simon Fraser University news — February 19, 2014

New Trial Advances Cell-Based Immune Therapy for Certain Leukemias
Julie Grisham, Memorial Sloan Kettering research news — February 20, 2014

New sitting risk: disability after 60
Regardless of exercise, too much sedentary time is linked to major disability after 60″
Maria Paul, Northwestern University news — February 19, 2014

Two proteins compete for one docking station on a growth factor; one promotes metastasis, the other blocks it
“Rivals’ relative expression levels in cancer cells could be biomarkers for prognosis, treatment”
MD Anderson Cancer Center, University of Texas, News Room — January 23, 2014

Ultrasound training should be implemented early into medical education programmes
World Heart Federation press releases — January 24, 2014

Why Vitamins May Be Bad for Your Workout
Gretchen Reynolds, Well blog, New York Times — February 12, 2014

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January 2014: 3

RNA

Designer “Swiss-Army-Knife” Molecule Captures RNA from Single Cells in their Natural Tissue Environment
“Findings allow for better understanding of how tissue microenvironment affects gene expression in healthy and diseased cells”
Perelman School of Medicine News, University of Pennsylvania — January 13, 2014

Molecular Engines Star in New Model of DNA Repair
“Study reveals major role of RNA polymerase and other enzymes in DNA repair”
NYU Langone Medical Center News — January 8, 2014

Penn Biologists Establish New Method for Studying RNA’s Regulatory ‘Footprint’
Katherine Unger Baillie, University of Pennsylvania News — January 7, 2014

Little but lethal: Small RNAs coordinate bacterial attack on epithelial cells
Jim Sliva, American Society for Microbiology news — January 14, 2014

Respiration and lungs

Dietary fibres protect against asthma
Swiss National Science Foundation Newsroom — January 6, 2014

New Research May Boost Drug Efficacy in Treating Pulmonary Arterial Hypertension
Science Daily — January 7, 2014

Odor receptors discovered in lungs
“They’re just like those in your nose, but instead of conjuring up a cup of coffee, they might make you cough”
Diana Lutz, Washington University at St. Louis News — January 2, 2014

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