injecting electronic scaffolds into the brain
Injectable device delivers nano-view of the brain
Harvard Gazette — June 8, 2015
- Discovery of a way to inject nanofabricated electronic scaffolds into the brain without causing inflammation.
- Scaffolds, etched like microchips, can be precisely located to monitor and stimulate tissue processes and regenerate neurons. They are flexible and “like to interact with neurons.”
new techniques for profiling a single cell
Stephanie Dutchen, Harvard Medical News — May 21, 2015
- “Different cells in a tissue use the same genome in amazingly diverse ways…”
- …”even embryonic stem cells are not uniform…”
- Thousands of single cell profiles can be generated per day using the Drop-Seq and inDrops techniques. This is up from the previous profile generation rate of 96 single cell profiles per day.
Single-cell analysis hits its stride
Lisa Girard, Broad Communications — May 21, 2015
- Analyzing variations between the same cell type is faster and more straightforward now that each cell can be assigned a unique DNA barcode.
- Microfluidic techniques allow each cell to interact with an outside DNA fragment. The DNA breaks up the cell and “reverse transcribes” the cell’s mRNA into a unique DNA barcode.
- When the tissue cells are sequenced and sorted, variation can be traced back to an individual cell using its barcode.
- Labs can buy droplets with DNA fragments for use in barcoding for 6 cents each.