Archive for cell biology

june 2015

injecting electronic scaffolds into the brain

Injectable device delivers nano-view of the brain
Harvard Gazette — June 8, 2015

  • Discovery of a way to inject nanofabricated electronic scaffolds into the brain without causing inflammation.
  • Scaffolds, etched like microchips, can be precisely located to monitor and stimulate tissue processes and regenerate neurons. They are flexible and “like to interact with neurons.”

new techniques for profiling a single cell

Beyond Average
Stephanie Dutchen, Harvard Medical News — May 21, 2015

  • “Different cells in a tissue use the same genome in amazingly diverse ways…”
  • …”even embryonic stem cells are not uniform…”
  • Thousands of single cell profiles can be generated per day using the Drop-Seq and inDrops techniques. This is up from the previous profile generation rate of 96 single cell profiles per day.

Single-cell analysis hits its stride
Lisa Girard, Broad Communications — May 21, 2015

  • Analyzing variations between the same cell type is faster and more straightforward now that each cell can be assigned a unique DNA barcode.
  • Microfluidic techniques allow each cell to interact with an outside DNA fragment. The DNA breaks up the cell and “reverse transcribes” the cell’s mRNA into a unique DNA barcode.
  • When the tissue cells are sequenced and sorted, variation can be traced back to an individual cell using its barcode.
  • Labs can buy droplets with DNA fragments for use in barcoding for 6 cents each.
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March 2014: 3

Chips that Listen to Bacteria
School of Engineering and Applied Science, Columbia University — February 28, 2014

Emergency Alert in the Cell
“Max Planck Scientists identify new mechanisms in the cellular stress response”
Max Planck Institute for Biochemistry — February 28, 2014

It slices, it dices, and it protects the body from harm
Princeton Journal Watch, Princeton University — February 28, 2014

Negative plus
“Researchers strengthen continuous protein evolution system”
Peter Reuell, Harvard University News Office — February 25, 2014

Optical nanotweezers for control of nano-objects
“Trapping and moving an individual nano-object in 3D”
The Institute of Photonic Sciences — March 3, 2014

Tumor Growth Checked
“New therapy releases brakes on immune response in metastatic melanoma”
Robert Levy, Harvard Medicine news — March 4, 2014

Understanding PP1, the ubiquitous enzyme
David Orenstein, Media Contact, Brown University — March 3, 2014

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